After securing the cat on my lap by way of cheesy bribery, I grab him by the back of the head and paint his nose with cheese. While he is distracted, I plan my pill attack. The trick is to dab cheese on your finger, poke the pill with the cheese, then shove the finger down the cat's throat. The cheese will wipe off on the cat's tongue, and since the pill was to the front of the mess, it is the first thing swallowed.
And, since Pico is a tad stupid, he will make the ick-face, then recover and lick my finger clean of cheese.